Description of an incidence-based model for Assessing comorbidity patterns in disease natural history

نویسنده

  • Victor A Kiri
چکیده

BACKGROUND Patients with a chronic disease often suffer from other diseases called comorbidities, which can be important factors in the assessment of risks associated with the disease and its management. However, comorbidities can pose important methodological issues because factors such as time, age, duration and the disease can influence their impact on the risk of interest. METHODS To identify comorbidities of a chronic disease, it is common practice to construct 2 separate cohorts of patients-a set with the disease and another as a random sample of patients free of the disease-and compare the event rates for each candidate's comorbidity over a specific period between the 2, while accounting for factors which may confound the results. We describe an incidence-based alternative approach that exploits the longitudinal properties of observational databases to track incident event rates along the natural history of the chronic disease. We illustrate it in a retrospective cohort of patients with chronic obstructive pulmonary disease (COPD) aged 50 and above-each patient with COPD was matched with another without COPD on certain confounding factors. RESULTS We obtained 24 079 matched pairs. We found that chronic conditions such as lung cancer, asthma, fracture and osteoporosis were more common in patients with COPD. We also found evidence of time-varying associations. CONCLUSIONS Our findings in COPD suggest that time is an important factor and comorbidity studies which are based on information in a single fixed period (such as first year postdiagnosis of COPD) are more likely to report spurious associations.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی علل زیربنایی وفرهنگی همبودی اختلال افسردگی عمده و وسواس فکری در بیماران مراجعه کننده به کلینیک و مراکز درمانی روانشناسی وروانپزشکی شهر تهران

Abstract Introduction: The diagnosis of the disease from another disease for the patient and the therapist is very important and it happens in the diagnostic process.  When the disease has more than one disorder axis, we face with multiple diagnose or comorbidity. So, the research investigated underlying factors of comorbidity of OCD and major depression and cultural factors re...

متن کامل

Exploring the spatial patterns of three prevalent cancer latent risk factors in Iran; Using a shared component model

Background and aims: The aim of this study was the modeling of the incidence rates of Colorectal, breast and prostate cancers using a shared component model in order to explore the spatial pattern of their shared risk factors (i.e., obesity and low physical activity) affecting on cancer incidence, and also to estimate the relative weight of these shared components. Methods: In this study,...

متن کامل

1. Steverding D. The history of leishmaniasis. Parasit Vectors. 2017; 10: 82. 2. Norouzinezhad F, Ghaffari F, Norouzinejad A, Kaveh F, Gouya MM. Cutaneous leishmaniasis in Iran: Results from an epidemiological study in urban and rural provinces. As

  Background and Objectives: Environmental conditions in different geographical areas provide a basis for the spread of some diseases. Cutaneous leishmaniasis is a serious threat to public health and is one of the arthropod-borne diseases. The prevalence and distribution of this disease is affected by environmental and climatic factors. The aim of this study was to model the Spatio-temporal va...

متن کامل

خواندن معماری؛ چیستی، چرایی و چگونگی در جستجوی مدلی برای آشنایی با تاریخ معماری ایران و نقش آن در سپهر معماری

Understanding the invaluable history of Iranian archi­tecture and utilizing its sustainable bases, principles and patterns can help us improve architecture both in the present and in the future. To understand Ira­nian architecture, it is essential that we can read it thoroughly and correctly; but before that, we need to have a comprehensive definition of it. So, the main question of this resear...

متن کامل

Association of Dietary Fat Pattern and Incidence of Cardiovascular Disease, Hypertension and Chronic Kidney Disease: Tehran Lipid and Glucose Study

Introduction: Cardiovascular disease (CVD), hypertension (HTN) and chronic kidney disease (CKD) are chronic conditions of recent decades, and dietary intakes play an important role in their prevention. The purpose of this study was to examine the association between dietary fat pattern and incidence of these conditions. Materials and Methods: Participants of the third phase (2006-2008) of the T...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2016